Too many women with fibroids—non-cancerous tumors of the uterus—get hysterectomies. In fact, fibroids are the top reason women in the U.S. get hysterectomies. Because it’s such a serious surgery, many women opt for less invasive fibroid treatments. But now, researchers at Michigan State University are trying to figure out why fibroids form in the first place. And, in doing so, they hope to keep every woman from being pushed towards hysterectomy because of fibroid tumors.
Genes and Fibroids: The Newly Discovered Connection
In the course of this study, researchers at MSU’s College of Human Medicine discovered that HOXA13, a gene associated with fibroids, was connected to a process, known as homeotic transformation, that causes uterine muscle cells to turn into cells more typically found inside your cervix.
“It’s a cell type in a position where it doesn’t belong,” explained lead researcher Dr. Jose Teixeira said. “This was a surprise.”
But this discovery isn’t just informative: it could change the way we treat fibroids. Specifically, new treatments could target the chain of events that causes your cells to change. That way, you could treat existing tumors with less invasive treatments, such as Uterine Fibroid Embolization. Then, you could use molecular therapy to prevent any new tumors from forming.
As Teixeira explains, “The discovery that fibroid tumors have characteristics of cervical cells could be a key to better treatments. For example, among pregnant women, the cervix typically softens just before delivery. Figuring out what causes the cervix to soften could suggest new therapies that soften the fibroid tumors and prevent or inhibit their growth.” And, if that works out, you could eliminate any hysterectomy discussions!
What’s Next for Fibroid Research?
While new therapies are still going to take a while, this research is already changing the way scientists study fibroids. Now, the National Institutes of Health (NIH) is funding a follow-up fibroid study. It’s focus? Texeira says he wants to discover: “Is there a place where we can intervene? That’s the follow-up. If we can find out what’s causing the cervical softening, then we might be able to investigate treatment.” And that could stop fibroid growth before a tumor ever forms.
Sources: Cell Reports Journal